NHOROONDO UYE KUKUKA KWEKUTI ANESTHESIA INTRAVENOUS
Kupinzwa mutsinga kwezvinodhaka kwakatanga muzana remakore rechigumi nemanomwe apo Christopher Wren akabaya opium mumbwa achishandisa goose quill uye dundira renguruve uye imbwa inobva yaita 'stupefied'.Mumakore ekuma1930 hexobarbital uye pentothal zvakaunzwa mumakiriniki maitiro.
Maive muma1960s Pharmacokinetic umo mamodheru nemaequation eIV infusions akaumbwa uye muma1980s, komputa inodzorwa neIV infusion masisitimu akaunzwa.Muna 1996 chinangwa chekutanga chekudzora infusion system (iyo 'Diprufusor') yakaunzwa.
DEFINITION
A target controlled infusioninfusions inodzorwa nenzira yekuedza kuwana mushandisi inotsanangurwa dhaka rekuisa muchikamu chemuviri chekufarira kana matishu ekufarira.Pfungwa iyi yakatanga kutaurwa naKruger Thiemer muna 1968.
PHARMACOKINETITS
Ukuru hwekugovera.
Iri ndiro vhoriyamu inooneka umo mushonga unogoverwa.Inoverengwa nemaitiro: Vd = dose/concentration of drug.Kukosha kwayo kunoenderana nekuti inoverengerwa panguva zero - mushure me bolus (Vc) kana pakugadzikana mushure mekuiswa (Vss).
Clearance.
Clearance inomiririra huwandu hweplasma (Vp) kubva iyo mushonga unobviswa pane imwe unit nguva yekuzvidavirira pakubviswa kwayo kubva mumuviri.Clearance = Kubvisa X Vp.
Sezvo kubvumidzwa kunowedzera iyo hafu yehupenyu inodzikira, uye sezvo huwandu hwekugovera hunowedzera ndizvo zvinoita hafu yehupenyu.Clearance inogona zvakare kushandiswa kutsanangura kuti mushonga unokurumidza sei kufamba pakati pemakamuri.Mushonga unotanga kugoverwa mukati mechikamu chepakati usati wagoverwa kune peripheral compartments.Kana iyo yekutanga vhoriyamu yekugovera (Vc) uye inodiwa yekumisikidza yekurapa maitiro (Cp) ichizivikanwa, zvinokwanisika kuverenga iyo yekurodha dhizeti kuti iwane iyo kusungwa:
Kurodha dose = Cp x Vc
Inogonawo kushandiswa kuverenga bolus dose inodiwa kuti ikurumidze kuwedzera kusungirirwa panguva inopfuurira infusion: Bolus dose = (Cnew - Cactual) X Vc.Chiyero chekupinza kuchengetedza chimiro chakatsiga = Cp X Clearance.
Nyore infusion regimens haigone kudzikama mamiriro eplasma kudzika kusvika kanenge kashanu kukapetwa kwehafu yekubvisa hupenyu.Iyo inodiwa yekuisa inogona kuwanikwa nekukurumidza kana bolus dose inoteverwa neiyo infusion rate.
Nguva yekutumira: Nov-04-2023