Nhau

Nhoroondo uye Mhedzisiro yeVentvenous Anesthesia

Mbiri yemishonga inodakadza kudzokera kuZana regumi nenomwe apo Christopher Wren ichipinza opium kuti imbwa ichishandisa goose quill uye imbwa inova 'stand inova' stupefied '. Muma1930Obbarbital uye pentothal yakaunzwa mukuita kwekiriniki.

Yakanga iri muma1960s parmackinetic iyo mhando uye equations yeIV infusions yakaumbwa uye kuma1980, komputa inotongwa IV infusion masisitimu akaunzwa. Muna 1996 yekutanga chinangwa chakadzora infusion system (iyo 'diprufusor') yakaunzwa.

Tsanangudzo

A Target inodzorwa infusionKufukurwa kwakadzorwa nenzira yakadai sekuyedza kuwana mushandisi inotsanangurwa kusarudzika kwezvinodhaka munzvimbo yemuviri yekufarira kana tishu yekufarira. Pfungwa iyi yakatanga kutaurwa naKruger Thihemeri muna 1968.

Pharmacokinetics

Vhoriyamu yekugovera.

Uku ndiko kujekesa kunooneka uko mushonga unogoverwa. Iyo inoverengwa neiyo formula: vd = dosi / kushamwaridzana kwemishonga. Iko kukosha kwayo kunoenderana nekuti inoverengerwa panguva ye zero zero - mushure mekubhazi (VC) kana kuimba yakatsiga mushure mekufumura (vss).

Clearance.

Clearance inomiririra vhoriyamu yePlasma (vp) kubva kune iyo iyo mushonga unobviswa pane yuniti nguva yekubvumirana nekubviswa kwayo kubva mumuviri wayo. Clearance = kubviswa x vp.

Sezvo clearance inowedzera hafu-hupenyu hunodzora, uye sehuwandu hwekugovera hunowedzera kudaro ita hafu-hupenyu. Clearance inogona zvakare kushandiswa kurondedzera kuti kukurumidza kunoita mushonga pakati pemakomputa. Mushonga wacho unotanga kugoverwa mukati mekamuri yepakati usati wagoverwa kuPeripheral Compartments. Kana iyo yekutanga vhoriyamu yekuparadzira (VC) uye iyo yaunoda kushamwaridzana kwekurapa maitiro (CP) inozivikanwa, zvinokwanisika kuverenga iyo yekutakura dosi kuti izarame.

Loading dose = CP x vc

Inogona zvakare kuwerengera iyo bolus dose inodiwa kukurumidza kuwedzera kusunganidzwa panguva yekuenderera mberi influsion: Bolus dose = (Cnew - CNECUAL) X VC. Chiyero chekungwara kuchengetedza nyika yakatsiga = CP X clearance.

Simpince Funlion Regomeni haazowana yakasimba nyika plasma yekushambadzira kusvikira rinenge shanu dzakawanda dzekurara hafu yehupenyu. Iko kusvinura kwaunoda kunogona kuwanikwa nekukurumidza kana iyo bolus dofo ichiteverwa neinonhuhwirira.