Nhau

Iyo nhoroondo yekuvanzika-inodzorwa infusion

Target-inodzorwa infusion (Tci) Iyi nzira yekusawedzera iv zvinodhaka kuti uwane iyo mushandisi-inotsanangurwa yakafanotaurwa Muongororo iyi, isu tinotsanangura nheyo dzePharmacokinetic yeTCI, kuvandudzwa kweTCI Systems, uye nyaya dzehunyanzvi uye dzekuzvidzora dzakatumirwa mukuvandudza prototype. Isu tinotsanangura zvakare kuvhenekerwa kwezvirongo zviripo zviripo.

Chinangwa chemafomu ese ekutumira zvinodhaka kuri kuita uye kuchengetedza nguva yekurapa nguva yekudzivirira kwezvinodhaka, nepo kudzivisa kukanganisa kwakashata. IV zvinodhaka zvinowanzo kupihwa uchishandisa standard dosing nhungamiro. Kazhinji chete iyo chete yekuvhara yekuvhara iyo inobatanidzwa mune dosi ndeye metric yehukuru hwemurwere, kazhinji huremu hweIV anesthetics. Hunhu hwemurwere hwakadai sezera, bonde, kana kugadzira clearance clearance kazhinji isingabatanidzwi nekuda kwehukama hwemasvomhu hwakaomarara hwekuzvibata uku kuenda kuDose. Nhoroondo dzave paine nzira mbiri dzekutungamira IV zvinodhaka panguva yeanesthesia: Bolus dime uye kuenderera mberi kwekunyepedzera. Bolus madoses anowanzopihwa neakashongedzwa syringe. Inconsions inowanzopihwa pamwe neinfomasi yepombi.

Chero ipi neipi yekunyepedzera inodhonza inounganidza mumatehwe panguva yekuzvitakura zvinodhaka. Uku kuunganidzwa kunobatanidza hukama hwehukama pakati pehupamhi hwechiyero chakaiswa nekiriniki uye kusunganidzwa kwezvinodhaka mumurwere. A Propofol Influsion yezana zana Nekushandisa zvakanaka-nhungamiro-nheyo, makomputa anogona kuverenga kuti yakawanda sei zvinodhaka panguva yekufungidzira uye inogona kugadzirisa huwandu hwakagadzikana mumaplasma kana tishu hwekufarira, kazhinji uropi. Komputa yacho inokwanisa kushandisa iyo yakanakisa muenzaniso kubva kumabhuku, nekuti kuoma kwemasvomhu kwekubatanidza maitiro (uremu, bonde, uye kune hwaro hwemhando yechitatu yeanesthetic yekutakura, target-inodzorwa incsions (TCI). Ndiina TCI Systems, chiremba anopinda anodikanwa chinangwa chekuvhara. Komputa yacho inoverenga huwandu hwezvinodhaka, hununurwa semhondi uye incussions, inodikanwa kuti uzadzise nzvimbo yekutarisa uye inotungamira pombi yekunyepedzera kuti inunure iyo yakaverengerwa bolus kana infusion. Komputa iyi inogara ichiverengera kuti yakawanda sei mushonga.

Munguva yekuvhiya, mwero wekukurudzirwa kwekuvhiya kunogona kuchinja nekukurumidza nekukurumidza, zvichida chaizvo, kukurumidza kugadziriswa kwezvinodhaka. Mafambiro akajairwa haagone kuwedzera zvinokonzeresa zvinokwana zvinokurumidza kukakavara nekukasira kuwedzera mukukurudzirwa kana kuderedza kutarisisa kwakakwana kuti uwane nguva yekukurumidza kukurudzira. Kunzwisisa kujairika hakugone kuchengeta kutarisisa kwemishonga mumaplasma kana uropi panguva dzekusimudzira nguva dzose. Nekubatanidza PK Models, TCI Systems inogona kukurumidza kupindura kupindura sezvakakosha uye nenzira yakafanana kuchengeta ongororo dzakasimba pazvinenge zvakakodzera pazvinenge zvakakodzera. Iyo inogona kubatsirwa kune varembi ndeyekunyatsojeka kwegumi chegumi chechiitiko chechiitiko .3

Muongororo iyi, isu tinotsanangura zvirevo zveTCI, kuvandudzwa kweTCI Systems, uye nyaya dzehunyanzvi uye dzekuzvidzora dzakapihwa mukuvandudza prototope. Zvinyorwa zviviri zvekutevera zvinoperekedza zvinofukidza kushandiswa kwepasirese uye kuchengetedza nyaya zvine chekuita neiyi tekinoroji.4,5

Sezvo TCI Systems yakashanduka, vaongorori vakasarudza idiosyncratic mazwi emhando. TCI Systems yakaendeswa kuComputer-Yakabatsirwa Yese IV Anesthesia (CACTIA) YEMAHARA YAKAITWA PAMUSORO PAMUSORO PAMUSORO PAKUTI inogamuchirwa seiyo generic tsananguro yeTekinoroji.10