Muna 1968, Kruger-Theimer akaenzanisira mashandisirwo emhando dzemupharmacokinetic kugadzira marejisheni anoshanda. Iyi Bolus, Elimination, Transfer (BET) regimen ine:
bolus dose yakaverengerwa kuzadza nzvimbo yepakati (yeropa),
chiyero chenguva dzose infusion yakaenzana nechiyero chekubvisa,
infusion inobhadhara kuendesa kune peripheral tissues: [exponentially kuderera rate]
Tsika yechinyakare yaisanganisira kuverenga iyo infusion regimen yepropofol nenzira yeRoberts. A 1.5 mg / kg loading dose inoteverwa nekuwedzerwa kwe 10 mg / kg / awa iyo inoderedzwa kusvika kumazinga e8 uye 6 mg / kg / hr pamaminitsi gumi.
Effect saiti kunanga
Mhedzisiro huru yeanestheticintravenous agents ndiwo masedative uye hypnotic mhedzisiro uye saiti iyo mushonga unoshandisa izvi zvinokonzeresa, inonzi iyo mhedzisiro saiti iuropi. Sezvineiwo hazvigoneke mumakiriniki ekuita kuyera huropi hwepfungwa [effect site]. Kunyangwe tikakwanisa kuyera kutariswa kwehuropi, zvingave zvakakosha kuti tizive iyo chaiyo yekumisikidzwa kwedunhu kana kunyange receptor yekumisikidza uko mushonga unoshanda.
Kuwana nguva dzose propofol concentration
Mufananidzo uri pazasi unoratidza mwero wekupinzwa unodiwa pachiyero chinodzikira zvakanyanya mushure memushonga webolus kuitira kuchengetedza kugadzikana kweropa repropofol. Iyo inoratidza zvakare lag pakati peropa uye mhedzisiro saiti concentration.
Nguva yekutumira: Nov-05-2024